Effects of autologous stem cell therapy for fertility enhancement among women with premature ovarian insufficiency

Background: Premature ovarian insufficiency (POI) is a condition where the ovary loses its normal reproductive potential earlier than 40 years, compromising fertility. There no treatment for POI, only ovum or embryo donation. Autologous stem cell transplant (ASCOT) may be procedure that creates new eggs in ovaries of women with POI. The aim study was to find out efficacy ASCOT patients suffering from Methods: A total 50 were included according inclusion and exclusion criteria this prospective observational study. POI confirmed low levels anti-mullerian hormone (AMH) (<0.5 ng/dl), high level follicle stimulating (FSH) >25 ng/ml, number antral count (AFC) (<3 each ovary). Results: Results showed after therapy, mean AMH values increased by 0.48±0.306 FSH 2.73±3.98 but difference not statistically significant. AFC significantly decreased 1.33±0.625 at 1st post-stem-cell cycle. During second cycle, 0.110±0.051 4.63±1.49, respectively, 7.4±2.78. increase significant, decrease also significant compared baseline values. Conclusions: autologous therapy can have effect on women’s function It AFC, pregnancy rate 4% third cycle follow-up.